Improving Search-Based Schematic Layout by Parameter Manipulation

This paper reports on a method to improve the automated layout of schematic diagrams by widening the search space examined by the system. In search-based layout methods there are typically a number of parameters that control the search algorithm which do not affect the fitness function, but nevertheless have an impact on the final layout. We explore how varying three parameters (grid spacing, the starting distance of allowed node movement and the number of iterations) affects the resultant diagram in a hill- climbing layout system. Using an iterative process, we produce diagram layouts that are significantly better than those produced by ad-hoc parameter settings

Gesture-Based Input for Drawing Schematics on a Mobile Device

We present a system for drawing metro map style schematics using a gesture-based interface. This work brings together techniques in gesture recognition on touch-sensitive devices with research in schematic layout of networks. The software allows users to create and edit schematic networks, and provides an automated layout method for improving the appearance of the schematic. A case study using the metro map metaphor to visualize social networks and web site structure is described

Exploring Local Optima in Schematic Layout

In search-based graph drawing methods there are typically a number of parameters that control the search algorithm. These parameters do not affect the ?tness function, but nevertheless have an impact on the ?nal layout. One such search method is hill climbing, and, in the context of schematic layout, we explore how varying three parameters (grid spacing, the starting distance of allowed node movement and the number of iterations) affects the resultant diagram. Although we cannot characterize schematics completely and so cannot yet automatically assign parameters for diagrams, we observe that when parameters are set to values that increase the search space, they also tend to improve the ?nal layout. We come to the conclusion that hillclimbing methods for schematic layout are more prone to reaching local optima than had previously been expected and that a wider search, as described in this paper, can mitigate this, so resulting in a better layout

Improving Automated Layout Techniques for the Production of Schematic Diagrams

This thesis explores techniques for the automated production of schematic diagrams, in particular those in the style of metro maps. Metro map style schematics are used across the world, typically to depict public transport networks, and therefore benefit from an innate level of user familiarity not found with most other data visualisation styles. Currently, this style of schematic is used infrequently due to the difficulties involved with creating an effective layout – there are no software tools to aid with the positioning of nodes and other features, resulting in schematics being produced by hand at great expense of time and effort. Automated schematic layout has been an active area of research for the past decade, and part of our work extends upon an effective current technique – multi-criteria hill climbing. We have implemented additional layout criteria and clustering techniques, as well as performance optimisations to improve the final results. Additionally, we ran a series of layouts whilst varying algorithm parameters in an attempt to identify patterns specific to map characteristics. This layout algorithm has been implemented into a custom-written piece of software running on the Android operating system. The software is targeted at tablet devices, using their touch-sensitive screens with a gesture recognition system to allow users to construct complex schematics using sequences of simple gestures. Following on from this, we present our work on a modified force-directed layout method capable of producing fast, high-quality, angular schematic layouts. Our method produces superior results to the previous octilinear force-directed layout method, and is capable of producing results comparable to many of the much slower current approaches. Using our force-directed layout method we then implemented a novel mental map preservation technique which aims to preserve node proximity relations during optimisation; we believe this approach provides a number of benefits over the the more common method of preserving absolute node positions. Finally, we performed a user study on our method to test the effect of varying levels of mental map preservation on diagram comprehension

Bowled out for a duck before picking up a bat: identifying women’s perceived barriers and lived experiences of cricket within the City of Lincoln

Gender inequality in sport has received significant attention from sports development initiatives and sociologists of sport. Gender inequality describes the structuring of aspects of society that favours one gender over another. Feminist academic literature is heavily focused around how the inequality is perpetuated in society (Hargreaves, J. (2000) Heroines of Sport: ‘The politics of difference and identity’. London: Routledge.). The prevalence of gender inequality is reflected in women’s participation levels in typically masculine sports such as cricket. Approximately 0.08% of the female population take part in cricket in the UK, which suggests there are inherent barriers to women’s participation (Sport England, 2011, Active People Survey 2011). This problem is something that has been highlighted as a substantial aim that the legacy of the 2012 London Olympics can help overcome (London Organising Committee of the Olympic and Paralympics games Ltd (2008) Diversity and Inclusion strategy). The present study builds on previous work to increase opportunities for women to participate in cricket (Hibberd et al 2011; ‘Not Just a Boys Game’: Programme evaluation of a multi-agency cricket intervention designed to reduce gender inequity in a city in the East of England.’Paper presented at the student BASES 2011 conference). The principal aim of this study is to investigate the perceived barriers that active women feel prevent or inhibit their participation in cricket. A case study approach will be adopted, focusing on six women’s community and University sports clubs in Lincoln, in conjunction with Lincolnshire Cricket board (LCB). Women will be recruited from an array of social backgrounds, with different abilities, ages and experiences of sport. A mixed method approach utilising both questionnaires and semi-structured group interviews will be employed (Bryman, A. (1988) Quantity and Quality in Social Research. London: Routledge). A theory driven approach to understanding women’s perceived barriers to participation in cricket will be adopted. The project will enable researchers to gain a better understanding of the reasons why women find access to certain sports easier than others. This information will allow researchers to make recommendations for widening participation in women’s cricket, with a view to increasing the viability of women’s participation in cricket locally

Biomechanical analysis of the penalty-corner drag-flick of elite male and female hockey players

The aim of this study was to analyse the kinematic sequencing in the penalty-corner drag-flicks of elite male and female field hockey players of international calibre. Thirteen participants (one skilled male drag-flicker and six male and six female elite players) participated in the study. An optoelectronic motion analysis system was used to capture the drag-flicks with six cameras, sampling at 250 Hz. Select ground reaction force parameters were obtained from a force platform which registered the last support of the front foot. Twenty trials were captured from each subject. Both player groups showed significantly (p < 0.05) smaller ball velocity at release, peak angular velocity of the pelvis, and negative and positive peak angular velocities of the stick than the skilled subject. Normalised ground reaction forces of the gender groups were also smaller than that of the skilled drag-flicker. By comparing these players we established that the cues of the skill level are a wide stance, a whipping action (rapid back lift) of the stick followed by an explosive sequential movement of the pelvis, upper trunk and stick

Information (and library) science at City University London; 50 years of educational development

The development of education for information and library science at City University London over a 50-year period is described in this article. The development of the Masters course in Information Science, and the later equivalent courses in Library Science and in Information Management in the Cultural Sector are described in detail, together with shorter-lived Masters courses in pharmaceutical and health information. The rationale for changes to the courses, and the influence of the professional and educational contexts, are analysed. Issues emerging from this analysis are discussed in seven themes: the nature of the discipline; the library/information spectrum; the student group; the academic/professional balance; curriculum design; local and global issues; and teaching methods. The discussions of the courses are set in the wider context of changes in library/information education over the period in the UK and worldwide

Quantum Dot Targeting with Lipoic Acid Ligase and HaloTag for Single-Molecule Imaging on Living Cells

We present a methodology for targeting quantum dots to specific proteins on living cells in two steps. In the first step, Escherichia coli lipoic acid ligase (LplA) site-specifically attaches 10-bromodecanoic acid onto a 13 amino acid recognition sequence that is genetically fused to a protein of interest. In the second step, quantum dots derivatized with HaloTag, a modified haloalkane dehalogenase, react with the ligated bromodecanoic acid to form a covalent adduct. We found this targeting method to be specific, fast, and fully orthogonal to a previously reported and analogous quantum dot targeting method using E. coli biotin ligase and streptavidin. We used these two methods in combination for two-color quantum dot visualization of different proteins expressed on the same cell or on neighboring cells. Both methods were also used to track single molecules of neurexin, a synaptic adhesion protein, to measure its lateral diffusion in the presence of neuroligin, its trans-synaptic adhesion partner.National Institutes of Health (U.S.) (R01 GM072670)Camille & Henry Dreyfus FoundationMassachusetts Institute of Technology. Computational and Systems Biology Program. MIT-Merck Postdoctoral Fellowshi

Social preferences and network structure in a population of reef manta rays

Understanding how individual behavior shapes the structure and ecology ofpopulations is key to species conservation and management. Like manyelasmobranchs, manta rays are highly mobile and wide ranging species threatened byanthropogenic impacts. In shallow-water environments these pelagic rays often formgroups, and perform several apparently socially-mediated behaviors. Group structuresmay result from active choices of individual rays to interact, or passive processes.Social behavior is known to affect spatial ecology in other elasmobranchs, but this isthe first study providing quantitative evidence for structured social relationships inmanta rays. To construct social networks, we collected data from more than 500groups of reef manta rays over five years, in the Raja Ampat Regency of West Papua.We used generalized affiliation indices to isolate social preferences from non-socialassociations, the first study on elasmobranchs to use this method. Longer lastingsocial preferences were detected mostly between female rays. We detectedassortment of social relations by phenotype and variation in social strategies, with theoverall social network divided into two main communities. Overall network structurewas characteristic of a dynamic fission-fusion society, with differentiated relationshipslinked to strong fidelity to cleaning station sites. Our results suggest that fine-scaleconservation measures will be useful in protecting social groups of M. alfredi in theirnatural habitats, and that a more complete understanding of the social nature of mantarays will help predict population response

Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue

The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play vital roles in protein folding, redox control, and disease. Here, we have shown that a single residue strongly modifies both the redox properties of thioredoxin fold proteins and their ability to interact with substrates. This residue is adjacent in three-dimensional space to the characteristic CXXC active site motif of thioredoxin fold proteins but distant in sequence. This residue is just N-terminal to the conservative cis-proline. It is isoleucine 75 in the case of thioredoxin. Our findings support the conclusion that a very small percentage of the amino acid residues of thioredoxin-related proteins are capable of dictating the functions of these proteins